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tecovirimat will improve the degree or impact of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Check. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse outcomes if coadministered with delicate substrates of these enzymes.butabarbital will lower the extent or outcome of diazepam by affecting hepatic/